Cocaine abuse may contribute to the diverse forms of renal injury. We report a case of a pregnant woman who developed a large subcapsular renal haematoma after cocaine intoxication at 18-week gestation. She stabilized on conservative management and presented again at 29-week gestation with pre-eclampsia, acute renal failure and fetal demise. She required caesarean section delivery and intensive antihypertensive therapy to control severe pre-eclampsia associated with cocaine intoxication. This case is unique in that it is the first report of cocaine intoxication in pregnancy complicated by subcapsular haemorrhage. We discuss the possible mechanisms for the occurrence of this complication.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477950PMC
http://dx.doi.org/10.1093/ndtplus/sfq015DOI Listing

Publication Analysis

Top Keywords

cocaine intoxication
16
acute renal
8
renal failure
8
cocaine
5
spontaneous perinephric
4
perinephric haemorrhage
4
haemorrhage acute
4
renal
4
failure pregnancy
4
pregnancy cocaine
4

Similar Publications

The emergence of new psychoactive substances (NPS) in the global drug market since the 2000s has posed major challenges for regulators and law enforcement agencies. Among these, synthetic cathinones have gained prominence due to their stimulant effects on the central nervous system, leading to widespread recreational use. These compounds, often marketed as alternatives to illicit stimulants such as amphetamines and cocaine, have been linked to numerous cases of intoxication, addiction and death.

View Article and Find Full Text PDF

Objectives: The accurate identification of Emergency Department (ED) encounters involving opioid misuse is critical for health services, research, and surveillance. We sought to develop natural language processing (NLP)-based models for the detection of ED encounters involving opioid misuse.

Methods: A sample of ED encounters enriched for opioid misuse was manually annotated and clinical notes extracted.

View Article and Find Full Text PDF

BACKGROUND Malignant hyperthermia (MH) and anesthesia-induced rhabdomyolysis (AIR) are rare, yet life-threatening complications that need prompt therapeutic actions and logistic preparedness for treatment success. Both conditions are triggered by general anesthetics, particularly volatiles and depolarizing muscle relaxants. In comparison with MH, which is an inherited pharmacogenomic disease of calcium channel receptor subpopulation and arises only after trigger exposure, AIR has been described mostly in patients with muscular dystrophies.

View Article and Find Full Text PDF
Article Synopsis
  • * A machine learning approach found that combining the SN and CEN provided a high accuracy of 73.4% in distinguishing CUD patients from healthy controls, indicating their importance in addiction stages over the DMN.
  • * Connectivity analysis showed reduced connectivity in the DMN and SN but increased connectivity in the CEN among CUD patients, suggesting these changes could be potential biomarkers for the severity of addiction.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the distribution of the synthetic cathinone MDPHP in post-mortem specimens of a 30-year-old man, highlighting high concentrations in urine and gastric content, suggesting potentially lethal levels.
  • - Various toxicological analyses, including gas chromatography and liquid chromatography, were used to measure MDPHP and other substances, with no evidence of recent cocaine injection found.
  • - Findings indicated that MDPHP levels were significantly higher compared to previously reported fatal cases, leading the researchers to conclude that the individual's death was likely due to MDPHP overdose.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!