AI Article Synopsis
- EEG data captures a wide range of brain activity, from very slow to high-frequency bands, with high-frequency oscillations (HFOs) being particularly important for understanding epilepsy.
- HFOs, especially ripple and fast ripple oscillations, are linked closely to the potential for seizures and may serve as biomarkers for epileptogenicity, making their study critical for epilepsy treatment.
- Advances in technology now allow for the noninvasive detection of fast oscillations (FOs) in the gamma and ripple bands, broadening research opportunities and implications for epilepsy monitoring and surgery.
Article Abstract
Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
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| http://dx.doi.org/10.18926/AMO/55201 | DOI Listing |
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