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Vertebral osteomyelitis in patients with infective endocarditis: prevalence, risk factors and mortality.
Eur J Clin Microbiol Infect Dis
January 2025
Department of Cardiology, Noordwest Hospital, Alkmaar, The Netherlands.
Purpose: Infective endocarditis (IE) can be complicated by vertebral osteomyelitis (VO). This study investigates risk factors associated with VO in patients with infective endocarditis, and 6-month mortality and relapse rates in patients with IE and concomitant VO.
Methods: We performed a observational study in two hospitals between September 2016 and October 2022.
A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.
Sci Rep
December 2024
Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
This paper introduces an evidence-based, design-of-experiments (DoE) approach to analyze and optimize drug delivery systems, ensuring that release aligns with the therapeutic window of the medication. First, the effective factors and release data of the system are extracted from the literature and meta-analytically undergo regression modeling. Then, the interaction and correlation of the factors to each other and the release amount are quantitatively assessed.
View Article and Find Full Text PDFThermosensitive multivesicular liposomal hydrogel: a potential platform for loco-regional drug delivery in the treatment of osteomyelitis caused by antibiotic-resistant biofilm-forming bacteria.
Lett Appl Microbiol
October 2024
Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
Biofilm-mediated osteomyelitis presents significant therapeutic challenges. Given the limitations of existing osteomyelitis treatment approaches, there is a distinct need to develop a localized drug delivery system that is biocompatible, biodegradable, and capable of controlled antibiotic release. Multivesicular liposomes (MVLs), characterized by their non-concentric vesicular structure, distinct composition, and enhanced stability, serve as the system for a robust sustained-release drug delivery platform.
View Article and Find Full Text PDFArticle Synopsis
- * They prepared drug-loaded microspheres using an emulsion ultrasonic method and characterized them through various techniques, revealing a strong, porous structure and effective drug loading rates.
- * The results demonstrated that the combined release of BMP-2 and VAN promoted osteogenic differentiation in stem cells, helping in the formation of new bone tissue.
NASCI case of the month: extensive ascending aortic graft infection with underlying chronic sternal osteomyelitis-a rare and high-risk complication.
Int J Cardiovasc Imaging
July 2024
Division of Cardiovascular Imaging, Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Thoracic aortic graft infections are infrequent yet grave complications of cardiovascular surgery. Risk factors include prolonged operative time, postoperative wound infections, and patient-specific risk factors like diabetes or malnutrition (Van Hemelrijck et al., Vessel Plus 6:47, 2022).
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