Irvingia malayana wax (IW) is majorly composed of esters of medium chain fatty acids. Its melting point is low and closed to the body temperature. This study aimed at investigating the potential of IW as a matrix-forming agent and evaluate the effect of soluble channeling agents on the release of diclofenac sodium (DS) from IW matrix tablets. The preformulation study by infrared spectroscopy and differential scanning calorimetry showed no incompatibility between IW and DS or soluble channeling agents, namely PEG 4000, PEG 6000 and lactose. IW retarded the release of DS from the matrix tablets more efficiently than carnauba wax due to its greater hydrophobicity and its ability to become partial molten wax at 37° C. Factors affecting the release of DS from IW matrix were drug concentrations, and types and concentrations of channeling agents. The release of DS significantly improved when DS concentration reached approximately 33%. The fast dissolving channeling agent, lactose, could enhance the drug release rate more effectively than PEG 4000 and PEG 6000, respectively. The linear relationship between the DS release rate and the concentration of the chosen channeling agent, PEG 6000, was found (r=0.9866).
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nitrate assimilation pathway is impacted in young tobacco plants overexpressing a constitutively active nitrate reductase or displaying a defective CLCNt2.
BMC Plant Biol
November 2024
PMI R&D, Philip Morris Products S.A., Quai-Jeanrenaud 5, Neuchâtel, 2000, Switzerland.
Background: We have previously shown that the expression of a constitutively active nitrate reductase variant and the suppression of CLCNt2 gene function (belonging to the chloride channel (CLC) gene family) in field-grown tobacco reduces tobacco-specific nitrosamines (TSNA) accumulation in cured leaves and cigarette smoke. In both cases, TSNA reductions resulted from a strong diminution of free nitrate in the leaf, as nitrate is a precursor of the TSNA-producing nitrosating agents formed during tobacco curing and smoking. These nitrosating agents modify tobacco alkaloids to produce TSNAs, the most problematic of which are NNN (N-nitrosonornicotine) and NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone).
View Article and Find Full Text PDFInvestigation of In Situ Gelation Behavior and Enhanced Oil Recovery Ability of Polymer Gel Used for Controlling CO Channeling in Tight Fractured Reservoir.
Gels
November 2024
College of Earth Science and Resources, Chang'an University, Xi'an 710100, China.
Article Synopsis
- * This study examines the gelation behavior of crosslinked phenolic resin gel using a stainless microtube to simulate fractured porous media, finding that higher polymer and crosslinker concentrations lead to stronger gels and faster gelation times.
- * Results indicate that static gelation occurs more quickly in the microtube compared to bulk gelation, and increasing polymer concentration enhances oil recovery, with a notable increase from 3.53% to 4.73% as concentration rises from 3000 mg·L to 4000 mg·L.
Construction and Mechanism of Janus Nano-Graphite Reinforced Foam Gel System for Plugging Steam in Heavy Oil Reservoirs.
Gels
November 2024
State Key Laboratory of Deep Oil and Gas, China University of Petroleum (East China), Qingdao 266580, China.
High-temperature steam injection is a primary method for viscosity reduction and recovery in heavy oil reservoirs. However, due to the high mobility of steam, channeling often occurs within the reservoir, leading to reduced thermal efficiency and challenges in enhancing oil production. Foam fluids, with their dual advantages of selective plugging and efficient oil displacement, are widely used in steam-injection heavy oil recovery.
View Article and Find Full Text PDFUse of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs and Cancer Risk.
JAMA Netw Open
November 2024
Division of Rheumatology, Department of Internal Medicine, University of Washington, Seattle.
Importance: The Oral Rheumatoid Arthritis Trial Surveillance demonstrated an increased cancer risk among patients with rheumatoid arthritis (RA) taking tofacitinib compared with those taking tumor necrosis factor inhibitors (TNFis). Although international cohort studies have compared cancer outcomes between TNFis, non-TNFi drugs, and Janus kinase inhibitor (JAKis), their generalizability to US patients with RA is limited.
Objective: To assess the comparative safety of TNFis, non-TNFi drugs, and JAKis among US patients with RA (ie, the cancer risk associated with the use of these drugs among these patients).
Second generation multiple channeling using platelet-rich plasma enhances cartilage repair through recruitment of endogenous MSCs in bone marrow.
Stem Cells Transl Med
December 2024
Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Dongjak-gu, Seoul 07061, Korea.
In the treatment of cartilage defects, a key factor is the adequate and specific recruitment of endogenous stem cells to the site of injury. However, the limited quantity and capability of endogenous bone marrow stem cells (BM MSCs) often result in the formation of fibrocartilage when using bone marrow stimulation (BMS) procedures. We engineered second-generation platelet-rich plasma (2G PRP) with defibrinogenating and antifibrinolytic agents for injection into the condyle of the right femur, followed by multiple channeling (MCh) 5 days later.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!