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Safety and efficacy of satralizumab in patients with generalised myasthenia gravis (LUMINESCE): a randomised, double-blind, multicentre, placebo-controlled phase 3 trial.
Lancet Neurol
February 2025
Department of Neurology, International University of Health and Welfare, Narita, Japan.
Background: Evidence from preclinical studies suggests that IL-6 signalling has the potential to modulate immunopathogenic mechanisms upstream of autoantibody effector mechanisms in patients with generalised myasthenia gravis. We aimed to assess the safety and efficacy of satralizumab, a humanised monoclonal antibody targeting the IL-6 receptor, in patients with generalised myasthenia gravis.
Methods: LUMINESCE was a randomised, double-blind, placebo-controlled, multicentre, phase 3 study at 105 sites, including hospitals and clinics, globally.
Involving people with lived experience when setting cerebral palsy research priorities: A scoping review.
Dev Med Child Neurol
January 2025
Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Aim: To describe research priority-setting activities for cerebral palsy (CP) that have been conducted worldwide involving people with lived experience, focusing on participant characteristics, methods employed, identified research priorities, and collaboration as research partners.
Method: The JBI scoping review approach was followed. Six electronic databases and grey literature were searched for all publications up to February 2024.
Supermicrosurgical Vascular Anastomosis-A Comparative Study of Lumen-Enhancing Visibility Techniques.
J Clin Med
January 2025
Department 11, Discipline Plastic and Reconstructive Surgery, Clinical Emergency Hospital of Bucharest, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
: The development of microsurgical techniques has enabled reconstructive versatility in various clinical scenarios. Supermicrosurgery is an advanced microsurgical technique ensuring precise reconstructions by operating on small-caliber vessels and nerves, with applications in reconstructive surgeries. : This study aims to compare the effectiveness of four low-cost training models, thereby improving surgical precision and reducing the learning curve for novice surgeons.
View Article and Find Full Text PDFTransforming Children's Attitudes Toward Insects Through In-School Encounters.
Insects
January 2025
Department of Entomology, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Each year, the Department of Entomology at Virginia Tech hosts an entomology-themed outreach event known as Hokie BugFest. This on-campus, festival-sized experience aims to educate the public about insects and other arthropods through hands-on activities, games, displays, and live arthropods. In 2021, due to the COVID-19 pandemic, Hokie BugFest and similar large public events were cancelled.
View Article and Find Full Text PDFWorkplace Health and Wellbeing in Small and Medium Sized Enterprises (SMEs): A Mixed Methods Evaluation of Provision and Support Uptake.
Int J Environ Res Public Health
January 2025
School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Today's challenging times highlight the need for workplaces to support employee wellbeing. Workplaces can offer a means to improve employee wellbeing and promote health initiatives. However, small and medium-sized enterprises (SMEs) are less likely than larger organizations to engage with workplace wellbeing initiatives or offer wellbeing provision.
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