A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys. | LitMetric

Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys.

Sci Data

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Published: March 2018

AI Article Synopsis

  • The research focuses on the differences in the development of pluripotency and primordial germ cells (PGCs) between mice and higher primates, particularly cynomolgus monkeys.
  • While pre-implantation development is fairly similar in humans and mice, post-implantation development shows significant differences that have not been well studied in primates.
  • The study provides a detailed single-cell transcriptome dataset of early embryonic cells from cynomolgus monkeys, offering valuable insights for understanding primate developmental biology, which may relate to human development.

Article Abstract

In mammals, the development of pluripotency and specification of primordial germ cells (PGCs) have been studied predominantly using mice as a model organism. However, divergences among mammalian species for such processes have begun to be recognized. Between humans and mice, pre-implantation development appears relatively similar, but the manner and morphology of post-implantation development are significantly different. Nevertheless, the embryogenesis just after implantation in primates, including the specification of PGCs, has been unexplored due to the difficulties in analyzing the embryos at relevant developmental stages. Here, we present a comprehensive single-cell transcriptome dataset of pre- and early post-implantation embryo cells, PGCs and embryonic stem cells (ESCs) of cynomolgus monkeys as a model of higher primates. The identities of each transcriptome were also validated rigorously by other way such as immunofluorescent analysis. The information reported here will serve as a foundation for our understanding of a wide range of processes in the developmental biology of primates, including humans.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477564PMC
http://dx.doi.org/10.1038/sdata.2017.67DOI Listing

Publication Analysis

Top Keywords

single-cell transcriptome
8
embryonic stem
8
stem cells
8
cynomolgus monkeys
8
cells pgcs
8
primates including
8
transcriptome early
4
early embryos
4
embryos cultured
4
cultured embryonic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!