AI Article Synopsis
- Clinical trials summarized the pharmacology and pharmacodynamics of esmolol, particularly in the presence of digoxin, morphine, and warfarin.
- The study investigated how esmolol affects these drugs and vice versa, monitoring vital signs and lab results.
- While some pharmacokinetic interactions were statistically significant, they were deemed clinically unimportant.
Article Abstract
The clinical pharmacology and pharmacodynamic data from several clinical trials are summarized. The pharmacokinetic profile of esmolol alone and in the presence of digoxin, morphine and warfarin was studied. Conversely the effect of esmolol on these drugs was monitored. No clinically important effects were observed on vital signs, blood chemistry or hematology. The pharmacokinetic interactions associated with administration of these drug combinations were statistically significant in several cases, but they were not considered to be of clinical importance.
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| http://dx.doi.org/10.1016/0002-9149(85)90911-7 | DOI Listing |
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