Introduction And Objectives: New drug-eluting stents (DES) designed to overcome the limitations of existing devices should initially be tested in preclinical studies. Our objective was to analyze the safety and efficacy of new biodegradable polymer-based DES compared with bare-metal stents (BMS) and commercially available DES in a model of normal porcine coronary arteries.
Methods: We randomly implanted 101 stents (BMS and biodegradable polymer-based sirolimus-eluting stents: 3 test stent iterations [BD1, BD2, and BD3], Orsiro, Biomime and Biomatrix) in the coronary arteries of 34 domestic pigs. Angiographic and histomorphometric studies were conducted 1 month (n = 83) and 3 months (n = 18) later.
Results: The stents were implanted at a stent/artery ratio of 1.31 ± 0.21, with no significant differences between groups. At 1 month, the new test stents (BD1, BD2 and BD3) showed less late loss and angiographic restenosis, as well as lower histologic restenosis and neointimal area (P < .0005), than the BMS. There were no differences in endothelialization, vascular injury, or inflammation between the new test stents and BMS, although the new stents showed higher fibrin deposition (P = .0006). At 3 months, all these differences disappeared, except for a lower neointimal area with the new BD1 stent (P = .027). No differences at any time point were observed between the new test stents and commercially available controls.
Conclusions: In this preclinical model, the new biodegradable polymer-based DES studied showed less restenosis than BMS and no significant differences in safety or efficacy vs commercially available DES.
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http://dx.doi.org/10.1016/j.rec.2017.05.021 | DOI Listing |
Biosens Bioelectron
December 2024
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, 721302, West Bengal, India. Electronic address:
Monitoring HO levels in live cells is essential due to its superior stability and possible severity inside the cell. The quest for a superior platform capable of detecting cellular-level hydrogen peroxide (HO) concentrations without necessitating the use of high-cost enzymes is of utmost importance. Here, the quantification of intracellular HO concentrations has been performed using silver metal polymer-based nonenzymatic electrochemical detection.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Quality Assurance, Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Maharashtra State 416112, India.
Natural polymers are crucial for developing sustainable biomedical solutions, as their bioactivity, biocompatibility, and biodegradability make them superior alternatives to synthetic materials. The objective of the study is to develop and characterize a chemically modified bael fruit gum (BFG) and pectin hydrogel to enhance antimicrobial activity. Due to BFG's anionic nature, it was chemically modified to introduce cationic groups, facilitating cross-linking with pectin.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
City of London Dental School, University of Bolton, London BL3 5AB, UK.
Polymers have become essential in advancing bone tissue engineering, providing adaptable bone healing and regeneration solutions. Their biocompatibility and biodegradability make them ideal candidates for creating scaffolds that mimic the body's natural extracellular matrix (ECM). However, significant challenges remain, including degradation by-products, insufficient mechanical strength, and suboptimal cellular interactions.
View Article and Find Full Text PDFPhytother Res
December 2024
Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.
Curcumin, a well-known bioactive component, has profound effects against colon cancer. However, the limitations are poor systemic absorption, off-target distribution, chemical instability, short half-life, and less concentration reaching tumor tissues. Several drug delivery systems have been evaluated so far to deliver effective concentrations of curcumin to the malignant tissues.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Cell state transitions are fundamental in biology, determining how cells respond to environmental stimuli and adapt to diseases and treatments. Cell surface-based sensing of geno/phenotypes is a versatile approach for distinguishing different cell types and states. Array-based biosensors can provide a highly sensitive platform for distinguishing cells based on the differential interactions of each sensing element with cell surface components.
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