SIRT4 Is a Regulator of Insulin Secretion. | LitMetric

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SIRT4 Is a Regulator of Insulin Secretion. | LitMetric

SIRT4 Is a Regulator of Insulin Secretion.

Elma Zaganjor Sejal Vyas Marcia C Haigis

Cell Chem Biol

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Published: June 2017

In a recent issue of Cell Metabolism, Anderson et al. (2017) report that SIRT4 regulates insulin sensitivity in the pancreas via activation of methylcrotonyl-CoA carboxylase 1 (MCCC1) by removal of dicarboxyacyl-lysine modifications. Thus, SIRT4 activates leucine catabolism and causes decreased secretion of insulin from the pancreas.

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http://dx.doi.org/10.1016/j.chembiol.2017.06.002	DOI Listing

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