Objectives: To examine the association between vagotomy and multiple sclerosis.
Methods: We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977-1995). Hazard ratios (HRs) for multiple sclerosis, adjusting for potential confounders were computed by means of Cox regression analysis.
Results: Median age of multiple sclerosis onset corresponded to late onset multiple sclerosis. No association with multiple sclerosis was observed for truncal vagotomy (0-37 year adjusted HR=0.91, 95% confidence interval [CI]: 0.48-1.74) or super-selective vagotomy (0-37 year adjusted HR=1.28, 95% CI: 0.79-2.09) compared with the general population.
Interpretation: We found no association between vagotomy and later risk of late onset multiple sclerosis.
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| http://dx.doi.org/10.1016/j.msard.2017.04.009 | DOI Listing |
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