AI Article Synopsis
- The reliability of analytical methods in forensic toxicology is crucial for avoiding unfair legal outcomes and is achieved through thorough method development.
- The process involves defining the method's purpose, selecting relevant analytes, choosing sample matrices, and setting up systems for separation and detection.
- Finally, method development culminates in an optimization phase followed by validation to ensure the method's effectiveness.
Article Abstract
Background: In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development.
Methods: The presented article will provide an overview on the process of developing methods for forensic applications.
Results: This includes the definition of the method's purpose (e.g. qualitative vs quantitative) and the analytes to be included, choosing an appropriate sample matrix, setting up separation and detection systems as well as establishing a versatile sample preparation.
Conclusion: Method development is concluded by an optimization process after which the new method is subject to method validation.
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| http://dx.doi.org/10.2174/1381612823666170622113331 | DOI Listing |
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