[Effect of chronic psychogenic stress on the characteristics of synaptic membrane receptors in the rat brain].

It has been shown that the 15-day stressing of rats by means of stochastic footshock combined with light flashes leads to a relatively stable "behavioral depression". Twenty-four hours after the last exposure to stress crude synaptosomes isolated from the whole brain demonstrated an increase in the KD of 3H-dihydroalprenolol specific binding and a lowering of the Bmax of 3H-WB-4101 specific binding sites. Specific binding of 3H-flunitrazepam changes inconclusively: the decrease in the KD is followed by a reduction in the concentration of receptors. Specific binding of 3H-imipramine by brain membranes remains unchanged under the above conditions.