In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-γ signaling.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685208PMC
http://dx.doi.org/10.1016/j.immuni.2017.05.010DOI Listing

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