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Dorsomedial prefrontal rTMS for depression in borderline personality disorder: A pilot randomized crossover trial.
J Affect Disord
March 2022
Department of Psychiatry, University of Toronto, Canada; Krembil Research Institute, University Health Network, Canada; Centre for Mental Health, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address:
Background: Recently, a small literature has emerged suggesting that repetitive transcranial magnetic stimulation (rTMS) may offer benefit for MDD even in BPD patients, perhaps by enhancing cognitive control, and/or disrupting excessive 'non-reward' activity in right orbitofrontal regions. This study aimed primarily to assess the therapeutic effects of dorsomedial prefrontal cortex (DMPFC)-rTMS against MDD symptoms in BPD patients, and secondarily to assess whether the therapeutic effects ensued via mechanisms of reduced impulsivity and core BPD pathology on clinical scales (BIS-11, ZAN-BPD) or of reduced alpha- and theta-band activity on EEG recordings of right orbitofrontal cortex..
View Article and Find Full Text PDFDorsomedial Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation for Tinnitus: Promising Results of a Blinded, Randomized, Sham-Controlled Study.
Ear Hear
July 2021
Laboratory of Panic and Respiration (LABPR), Institute of Psychiatry (IPUB), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Objectives: Tinnitus is the perception of sound in ears or head without corresponding external stimulus. Despite the great amount of literature concerning tinnitus treatment, there are still no evidence-based established treatments for curing or for effectively reducing tinnitus intensity. Sham-controlled studies revealed beneficial effects using repetitive transcranial magnetic stimulation (rTMS).
View Article and Find Full Text PDFBilateral Dorsomedial Prefrontal Cortex rTMS for Tinnitus Treatment: A Successful Case.
Eurasian J Med
February 2019
Laboratory of Panic & Respiration (LABPR), Institute of Psychiatry (IPUB), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
We present a successful tinnitus treatment case with intensity and distress reduction in a patient subjected to bilateral 10 Hz repetitive transcranial magnetic stimulation (rTMS) to the dorsomedial prefrontal cortex (DMPFC). Subjective tinnitus is the perception of sound in the ears or head when no corresponding external stimulus exists. Approximately 1%-2% of the population report severe tinnitus with daily life impairment.
View Article and Find Full Text PDFNumber of pulses or number of sessions? An open-label study of trajectories of improvement for once-vs. twice-daily dorsomedial prefrontal rTMS in major depression.
Brain Stimul
January 2019
MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Canada; Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; Krembil Research Institute, University Health Network, Canada. Electronic address:
Background: Repetitive transcranial magnetic stimulation (rTMS) shows efficacy in the treatment of major depressive episodes (MDEs), but can require ≥4-6 weeks for maximal effect. Recent studies suggest that multiple daily sessions of rTMS can accelerate response without reducing therapeutic efficacy. However, it is unresolved whether therapeutic effects track cumulative number of pulses, or cumulative number of sessions.
View Article and Find Full Text PDFBilateral DMPFC-rTMS Leads to Sustained Remission in Geriatric Treatment-Resistant Depression: A Case Report.
Psychiatr Danub
June 2017
Laboratory of Panic & Respiration (LABPR), Institute of Psychiatry (IPUB), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
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