The article presents the currents concepts on the mechanisms of brain lesions and development of cognitive impairment in diabetes mellitus (DM) including DM type 2. Metabolic and vascular mechanisms, oxidative stress, hyperglycemia, glutamate excitotoxicity, insulin insufficiency and brain insulin resistance, general vascular and microcirculatory disturbances, death of cortical neurons, decrease in the newly synthesized acetylcholine, activation of lipid peroxidation are considered. A review of the main domestic and international drugs used in clinical practice for treatment of cognitive impairment in patients with DM is presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.17116/jnevro20161167185-93 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease.
J Neuroinflammation
January 2025
Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, 85013, USA.
The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. However, its effects on the lipid transporters apolipoprotein E (ApoE) and fatty acid-binding protein 7 (Fabp7), which are crucial for the maintenance of myelin in white matter (WM) during the progression of AD remain underexplored. To evaluate the effects of APOEε4 on ApoE, Fabp7 and myelin in the WM of the frontal cortex (FC), we examined individuals carrying one ε4 allele that came to autopsy with a premortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI) and mild to moderate AD compared with non-carrier counterparts.
View Article and Find Full Text PDFBenefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder.
BMC Pediatr
January 2025
Institute of Neurodevelopment, Cognition, and Inclusive Education (INCEI), Ribeirão das Neves, Belo Horizonte, MG, Brazil.
Background: Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children and adolescents with ASD, analyze variations in priorities according to the levels of support and age groups of the participants, and categorize the goals according to the categories of the International Classification of Functioning, Disability, and Health (ICF). Additionally, this study aimed to evaluate changes in parents' performance and satisfaction with functional priorities after intervention with the Global Integration Method (Métodode Integração Global - MIG).
View Article and Find Full Text PDFAcceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive-compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-19 pandemic in a psychiatric outpatient department in Germany.
BMC Psychiatry
January 2025
Department of Psychiatry and Psychotherapy, Medical Faculty, Leipzig University, Leipzig, Germany.
Background: Cognitive behavior therapy (CBT) is the gold-standard treatment for obsessive-compulsive disorder (OCD). However, access to CBT and specialized treatments is often limited. This pilot study describes the implementation of a guided Internet-Based CBT program (ICBT) for individuals seeking treatment for OCD in a psychiatric outpatient department in Leipzig, Germany, during the COVID-19 pandemic.
View Article and Find Full Text PDFPrevious studies have suggested that systemic viral infections may increase risks of dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections is unknown. Determining this is important for anticipating the potential future incidence of dementia.
View Article and Find Full Text PDFThe pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study.
J Hum Hypertens
January 2025
Research Centre, Montreal Heart Institute, Montreal, QC, Canada.
Age-related arterial stiffness increases pulsatility that reaches the cerebral microcirculation, compromises cerebrovascular health and lead to cognitive decline. The presence of cardiovascular risk factors (CVRFs) such as high blood pressure can exacerbate this effect. Despite extensive research on the impact of antihypertensive treatments on reducing arterial stiffness, little is known about the impact of antihypertensive treatments on pulsatility in cerebral microcirculation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!