AI Article Synopsis
- Hepatitis C virus (HCV) infection can lead to chronic liver issues like cirrhosis and liver cancer, as well as various extrahepatic diseases due to its impact on both liver and lymphatic systems.
- The most notable consequences include mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma, which arise from prolonged B cell stimulation by the virus.
- The review focuses on the connections between chronic HCV infection and lymphoproliferative disorders, autoimmune disorders, and kidney damage.
Article Abstract
Hepatitis C virus (HCV) infection results in not only chronic hepatitis and subsequent complications as liver cirrhosis and hepatocellular carcinoma, but also in a significant number of other diseases, the so-called extrahepatic manifestations of chronic HCV infection. This is because of viral hepatotropicity and lymphotropicity. The most striking example of the course of chronic HCV infection, in which the infectious and inflammatory processes are concurrent with autoimmune disorders and carcinogenesis, is mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma. The pathogenesis of these diseases is based on the clonal expansion of B cells, which occurs under their prolonged stimulation with the virus or viral proteins. Part 1 of this review is devoted to the analysis of a correlation of chronic HCV infection with lymphoproliferative and autoimmune disorders, as well as its association with kidney injury.
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| http://dx.doi.org/10.17116/terarkh2016886105-113 | DOI Listing |
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