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Incorporating immune checkpoint inhibitors in epithelial ovarian cancer.
Gynecol Oncol
January 2025
GOG Foundation, Florida Cancer Specialists and Research Institute, West Palm Beach, FL 33401, United States of America. Electronic address:
Objective: Therapeutic interventions for epithelial ovarian cancer (EOC) have increased greatly over the last decade but improvements outside of biomarker selected therapies have been limited. There remains a pressing need for more effective treatment options that can prolong survival and enhance the quality of life of patients with EOC. In contrast to the significant benefits of immunotherapy with immune checkpoint inhibitors (CPI) seen in many solid tumors, initial experience in EOC suggests limited efficacy of CPIs monotherapy.
View Article and Find Full Text PDFRurality predisposes departure from gold-standard care, leading to delayed or accelerated access to surgery: insights from a scoping review.
Can J Surg
January 2025
From the Cumming School of Medicine, University of Calgary, Calgary, Alta. (Ebrahim, Sinha, Adedipe, Ahmad, Amyotte, Yang); the Canadian Global Surgery Trainees' Association affiliated with the International Student Surgical Network - InciSioN (Ebrahim, Sinha, Adedipe, Ahmad, Amyotte, Yang, Elsewify); the Faculty of Medicine and Health Sciences, Laval University, Québec City, Que. (Elsewify); the Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, Ont. (Sachal); the Sections of Pediatric Surgery and Plastic Surgery, Department of Surgery, University of Calgary, Calgary, Alta. (Fraulin); the Departments of Clinical Neurosciences and Surgery, University of Calgary, Calgary, Alta. (Gabriel); the Department of Distributed Learning and Rural Initiatives, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Perez, Johnston)
Background: Because tertiary centres are generally situated at urban sites, it is unclear whether patients in rural areas have the same access to surgical services that patients in urban areas do. We sought to map the North American evidence landscape of how rurality affects access to medically indicated surgeries and identify system-, patient-, and provider-level barriers that preclude urban-comparable care.
Methods: We carried out a systematic search adhering to PRISMA for Scoping Reviews methodology across PubMed, MEDLINE, Scopus, and Web of Science, encompassing literature from the last 26 years (January 2023).
Perspectives surrounding robotic total hip arthroplasty: a cross-sectional analysis using natural language processing.
Can J Surg
January 2025
From the Faculty of Medicine, Université de Montréal, Montréal, Que. (Levett); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Elkaim); the Department of Orthopaedic Surgery, McGill University, Jewish General Hospital, Montréal, Que. (Zukor, Huk, Antoniou)
Article Synopsis
- The study analyzed social media discussions about robotic total hip arthroplasty (THA) to understand public perspectives and sentiments.
- A total of 742 tweets were collected, with most focused on raising awareness, advertisements, and personal experiences, showing a generally positive tone.
- Key findings suggested that orthopedic surgeons can utilize social media for insights into patient views and advancements in robotic surgery.
IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced vascular permeability.
J Transl Med
December 2024
Institut de Recherche Biomédicale Des Armées (IRBA), 1, Rue du Lieutenant Raoul Batany, 92141, Clamart, France.
Background: Hemorrhagic shock (HS) corresponds to absolute hypovolemia creating an imbalance between oxygen supply and consumption. This causes an impaired hemostasis, a systemic inflammatory response, and microvascular permeability which can lead to multiple organ failure (MOF). There is no specific treatment for the endothelial dysfunction that plays a major role in the evolution towards MOF.
View Article and Find Full Text PDFRectal cancer - French intergroup clinical practice guidelines for diagnosis, treatment, and follow-up (TNCD, SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, SFP, RENAPE, SNFCP, AFEF, SFR, and GRECCAR).
Dig Liver Dis
December 2024
Department of Gastroenterology and Digestive Oncology, Reims University Hospital, Reims, France.
Background: This article summarizes the French intergroup guidelines regarding rectal adenocarcinoma (RA) management published in September 2023, available on the French Society of Gastroenterology website.
Methods: This work was supervised by French medical and surgical societies involved in RA management. Recommendations were rated from A to C according to the literature until September 2023.
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