Background: Chronic heroin use can cause a deficit of inhibitory function, leading to a loss of control over drug use. Exposure to drug-related cues is considered as one of the contributing factors. However, it is unclear whether there are dynamic changes on the effect of drug-related cues on response inhibition following prolonged abstinence.
Objective: The present study investigated the effect of drug-related cues on response inhibition in heroin abstainers at different abstinent phases.
Methods: 26 shorter-term (2-6 months) and 26 longer-term (19-24 months) male heroin abstainers performed on a modified two-choice Oddball task, which included two conditions: in the cued condition, neutral pictures served as the background of standard stimuli (yellow frame) and heroin-related pictures served as the background of deviant stimuli (blue frame), reversed in the controlled conditions.
Results: Compared to longer-term abstainers, mean reaction time (RT) for drug deviants in shorter-term abstainers was significantly longer. Shorter-term abstainers also showed markedly slower response to neutral deviants relative to drug deviants, but this tendency was not observed in longer-term abstainers. Nevertheless, both groups had similar RT for standard stimuli regardless of their paired background pictures.
Conclusion: Effect of drug-related cues on response inhibition remains at the early stage of abstinence; however, this effect may be reduced following a longer period of drug abstinence. Our findings highlight the importance of assessing and improving the ability of inhibiting drug-related cue reactivity during treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/00952990.2017.1283695 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [F]fallypride positron emission tomography.
Alcohol Clin Exp Res (Hoboken)
December 2024
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.
Methods: Young social drinkers (age 18.
Effect of acute treatment with the glucagon-like peptide-1 receptor agonist, liraglutide, and estrus phase on cue- and drug-induced fentanyl seeking in female rats.
Behav Pharmacol
February 2025
Department of Neural and Behavioral Sciences.
Opioid use disorder (OUD) is a crisis in the USA. Despite advances with medications for OUD, overdose deaths have continued to rise and are largely driven by fentanyl. We have previously found that male rats readily self-administer fentanyl, with evident individual differences in fentanyl taking, seeking, and reinstatement behaviors.
View Article and Find Full Text PDFDisrupting heroin-associated memory reconsolidation through actin polymerization inhibition in the nucleus accumbens core.
Int J Neuropsychopharmacol
December 2024
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Background: Understanding drug addiction as a disorder of maladaptive learning, where drug-associated or environmental cues trigger drug cravings and seeking, is crucial for developing effective treatments. Actin polymerization, a biochemical process, plays a crucial role in drug-related memory formation, particularly evident in conditioned place preference paradigms involving drugs like morphine and methamphetamine. However, the role of actin polymerization in the reconsolidation of heroin-associated memories remains understudied.
View Article and Find Full Text PDFInteroceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.
Curr Top Behav Neurosci
November 2024
Laureate Institute for Brain Research, Tulsa, OK, USA.
Article Synopsis
- * Dysfunction in interoceptive processing contributes to craving, emotional regulation issues, and decision-making challenges that drive addiction, with areas like the insula being significant in drug use, particularly nicotine.
- * The chapter employs a predictive coding framework to explain how disruptions in the brain's predictions of internal states can lead to compulsive drug-seeking behaviors, suggesting that targeted therapies like neuromodulation and mindfulness can help recalibrate these internal predictions for better treatment outcomes.
Attentional bias in tobacco use disorder using eye tracking: A systematic review.
Drug Alcohol Depend Rep
December 2024
University of Toronto, Department of Pharmacology & Toxicology, Toronto, Canada.
Background: Attentional bias, defined as the disproportionate attentional allocation towards drug-related stimuli, is well-demonstrated in substance use disorders. However, studies investigating attentional bias in tobacco use disorder have revealed inconclusive findings. In recent years, eye-tracking technology has emerged as an innovative technique for exploring attentional bias.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!