AI Article Synopsis
- The study examines the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous fluid of patients with various eye conditions to understand their correlation.
- 78 patients were grouped based on their vitreoretinal issues (macular hole/epiretinal membrane, retinal detachment, and diabetic retinopathy), and their IL-6 and TAT levels were measured and compared.
- Findings show significant differences in IL-6 and TAT levels among groups, with diabetes linked to higher IL-6 in retinal detachment cases, indicating that TAT levels may differ due to inflammation and specific eye tissue responses.
Article Abstract
Purpose: This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies.
Methods: Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups.
Results: A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups (P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies.
Conclusion: Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood-retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.
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| http://dx.doi.org/10.1080/02713683.2017.1313432 | DOI Listing |
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