AI Article Synopsis

  • Ultrahigh-field (UHF) transmit arrays for human head imaging enhance transmission efficiency and uniformity compared to traditional single-channel volume coils.
  • Decoupling poses a significant challenge in multi-channel array design, requiring a deeper understanding of element coupling and its influencing factors.
  • An analytical model utilizing dyadic Green's functions was developed to quickly assess the impedance matrix of the arrays, demonstrating effective decoupling and improved performance when loops are strategically overlapped.

Article Abstract

Ultrahigh-field (UHF) (≥7 T) transmit (Tx) human head surface loop phased arrays improve both the Tx efficiency (B /√P) and homogeneity in comparison with single-channel quadrature Tx volume coils. For multi-channel arrays, decoupling becomes one of the major problems during the design process. Further insight into the coupling between array elements and its dependence on various factors can facilitate array development. The evaluation of the entire impedance matrix Z for an array loaded with a realistic voxel model or phantom is a time-consuming procedure when performed using electromagnetic (EM) solvers. This motivates the development of an analytical model, which could provide a quick assessment of the Z-matrix. In this work, an analytical model based on dyadic Green's functions was developed and validated using an EM solver and bench measurements. The model evaluates the complex coupling, including both the electric (mutual resistance) and magnetic (mutual inductance) coupling. Validation demonstrated that the model does well to describe the coupling at lower fields (≤3 T). At UHFs, the model also performs well for a practical case of low magnetic coupling. Based on the modeling, the geometry of a 400-MHz, two-loop transceiver array was optimized, such that, by simply overlapping the loops, both the mutual inductance and the mutual resistance were compensated at the same time. As a result, excellent decoupling (below -40 dB) was obtained without any additional decoupling circuits. An overlapped array prototype was compared (signal-to-noise ratio, Tx efficiency) favorably to a gapped array, a geometry which has been utilized previously in designs of UHF Tx arrays.

Download full-text PDF

Source
http://dx.doi.org/10.1002/nbm.3759DOI Listing

Publication Analysis

Top Keywords

analytical model
8
mutual resistance
8
mutual inductance
8
coupling
6
array
6
model
6
mutual
5
analytical modeling
4
modeling insight
4
insight complex
4

Similar Publications

HIV-1 envelope broadly neutralizing antibodies represent a promising component of HIV-1 cure strategies. To evaluate the therapeutic efficacy of combination monoclonal antibodies (mAbs) in a rigorous nonhuman primate model, we tested different combinations of simian immunodeficiency virus (SIV) neutralizing mAbs in SIVmac251-infected rhesus macaques. Antiretroviral therapy-suppressed animals received anti-SIV mAbs targeting multiple Env epitopes spanning analytical treatment interruption (ATI) in 3 groups (n = 7 each): i) no mAb; ii) 4-mAb combination; and iii) 2-mAb combination.

View Article and Find Full Text PDF

The gonorrhoea care cascade in general practice: a descriptive study to explore gonorrhoea management utilising electronic medical records.

Sex Health

January 2025

Department of General Practice and Primary Care, Melbourne Medical School, University of Melbourne, Carlton, Vic, Australia; and Family Medicine and Primary Care, LKC Medicine, Nanyang Technological University, Singapore, Singapore.

Background Gonorrhoea notification rates in Australia have more than doubled between 2014 and 2019. We explored gonorrhoea testing patterns and management of gonorrhoea infection in general practice. Methods We analysed de-identified electronic medical record data for individuals who attended 73 Australian general practices (72 in the state of Victoria) between January 2018 and December 2020.

View Article and Find Full Text PDF

Systematic bias in malaria parasite relatedness estimation.

G3 (Bethesda)

January 2025

Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France.

Genetic studies of Plasmodium parasites increasingly feature relatedness estimates. However, various aspects of malaria parasite relatedness estimation are not fully understood. For example, relatedness estimates based on whole-genome-sequence (WGS) data often exceed those based on sparser data types.

View Article and Find Full Text PDF

This meta-review provides the first meta-analytic evidence from published meta-analyses examining the effectiveness of acute exercise interventions on cognitive function. A multilevel meta-analysis with a random-effects model and tests of moderators were performed in R. Thirty systematic reviews with meta-analyses (383 unique studies with 18,347 participants) were identified.

View Article and Find Full Text PDF

Dedenser: A Python Package for Clustering and Downsampling Chemical Libraries.

J Chem Inf Model

January 2025

Analytical Research & Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

The screening of chemical libraries is an essential starting point in the drug discovery process. While some researchers desire a more thorough screening of drug targets against a narrower scope of molecules, it is not uncommon for diverse screening sets to be favored during the early stages of drug discovery. However, a cost burden is associated with the screening of molecules, with potential drawbacks if particular areas of chemical space are needlessly overrepresented.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!