Acquired atresia of the external acoustic meatus is a rare pathological condition characterized by obliteration of the medial part of the external acoustic canal by a soft fibrous plug. The present article presents an overview of a series of cases of acquired atresia and stenosis of the external acoustic meatus with the description of etiology, pathogenesis, and methods for the treatment of this condition. In the majority of the cases, atresia develops at the final stage of granulation external otitis with or without an accompanying dermatological pathology. Another common cause of the acquired atresia of the external acoustic meatus is the fracture of the temporal bone as well as extensive ear surgery, radiation therapy and a neoplasm in the auditory passage. The surgical strategy for the management of the acquired atresia and stenosis of the external acoustic meatus consists, besides the excision of the fibrous plug, of the application of the cutaneous flaps and/or transplants to cover the bare parts of the bone portion of the affected external canal. In spite of such treatment, the state of the external acoustic canal remains unstable, and a relapse of its atresia and stenosis can not be wholly excluded.
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http://dx.doi.org/10.17116/otorino201782369-74 | DOI Listing |
Background: The increasing prevalence of cognitive impairment and dementia threatens global health, necessitating the development of accessible tools for detection of cognitive impairment. This study explores using a transformer-based approach to detect cognitive impairment using acoustic markers of spontaneous speech.
Method: Recordings of unstructured interviews from baseline visits were obtained from participants of The 90+ Study, a longitudinal study of individuals older than 90 years.
J Acoust Soc Am
January 2025
Department of Mechanical Engineering, Binghamton University, Binghamton, New York 13902, USA.
A study is presented of a method for creating an acoustic flow sensor that is generally compatible with current silicon microfabrication processes. An aim of this effort is to obtain a design consisting of a minimal departure from the existing designs employed in mass-produced silicon microphones. Because the primary component in all of these microphones is the cavity behind the pressure-sensing diaphragm, we begin with a study of the acoustic particle velocity within a cavity in a planar surface.
View Article and Find Full Text PDFOper Neurosurg (Hagerstown)
January 2025
Department of Neurosurgery, Yeditepe University School of Medicine, İstanbul, Türkiye.
Background And Objectives: The middle fossa approaches are tremendously versatile for treating small vestibular schwannomas, selected petroclival meningiomas, midbasilar trunk aneurysms, and lesions of the petrous bone. Our aim was to localize the internal acoustic canal and safely drill the petrous apex with these approaches. This study demonstrates a new method to locate the internal acoustic canal during surgery in the middle fossa.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
School of Civil and Transportation Engineering, Hebei University of Technology, Tianjin 300401, China.
Concrete, as the most widely used construction material globally, is prone to cracking under the influence of external factors such as mechanical loads, temperature fluctuations, chemical corrosion, and freeze-thaw cycles. Traditional concrete crack repair methods, such as epoxy resins and polymer mortars, often suffer from a limited permeability, poor compatibility with substrates, and insufficient long-term durability. Microbial biogrouting technology, leveraging microbial-induced calcium carbonate precipitation (MICP), has emerged as a promising alternative for crack sealing.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Oncolytic virotherapy has shown great promise in mediating targeted tumor destruction through tumor-selective replication and induction of anti-tumor immunity; however, obstacles remain for virus candidates to reach the clinic. These include avoiding neutralizing antibodies, preventing stimulation of the adaptive immune response during intravenous administration, and inducing sufficient apoptosis and immune activation so that the body's defense can work to eradicate systemic disease. We have developed a co-formulation of oncolytic viruses (OVs) with Imagent lipid-encapsulated, perfluorocarbon microbubbles (MBs) to protect the OVs from the innate and adaptive immune system.
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