Studies with methicillin-resistant (MRSA) strain COL have shown that the optimal resistance phenotype requires not only but also a large number of "auxiliary genes" identified by Tn mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).
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| http://dx.doi.org/10.1128/AAC.00313-17 | DOI Listing |
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