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Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway.
Arch Endocrinol Metab
January 2025
Fuzhou First General Hospital Affiliated with Fujian Medical University Department of Endocrinology FuzhouFujian China Department of Endocrinology, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes.
View Article and Find Full Text PDFThe effect of sciatic nerve block on sciatic nerve depth and pain level in patients with ankle fracture based on different approaches under ultrasound guidance.
J Foot Ankle Surg
January 2025
Anesthesia Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010000, China. Electronic address:
To investigate the clinical efficacy of using different approach sciatic nerve blocks on the sciatic nerve depth and pain degree in patients with ankle fracture. A retrospective analysis was conducted on 151 patients with ankle fractures who were admitted to the hospital from May 2020 to May 2023. The patients were divided into a control group (n=76) using the greater trochanteric plane approach (GTA) and an observation group (n=75) using the suprapopliteal approach (PA).
View Article and Find Full Text PDFTransthyretin variants impact blood-nerve barrier and neuroinflammation in amyloidotic neuropathy.
Brain
January 2025
Department of Neurology, National Taiwan University Hospital, Taipei, 100225, Taiwan.
Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a neurodegenerative disease caused by mutations in the gene encoding transthyretin (TTR). Despite amyloid deposition being pathognomonic for diagnosis, this pathology in nervous tissues cannot fully account for nerve degeneration, implying additional pathophysiology for neurodegeneration, which, however, has not yet been fully elucidated. In this study, neuroinflammation in ATTRv-PN was investigated by examining nerve morphometry, the blood-nerve barrier, and macrophage infiltration in the sural nerves of ATTRv-PN patients and the sciatic nerves of a complementary mouse system, i.
View Article and Find Full Text PDFImaging on the painful and compressed nerve: lower extremity.
Int Orthop
January 2025
Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.
Entrapment neuropathies of the lower extremity are often underdiagnosed due to limitations in clinical examination and electrophysiological testing. Advanced imaging techniques, particularly MR neurography and high-resolution ultrasonography (US), have significantly improved the evaluation and diagnosis of these conditions by enabling precise visualization of nerves and their surrounding anatomical structures. This review focuses on the imaging features of compressive neuropathies affecting the lumbosacral plexus and its branches, including the femoral, obturator, sciatic, common peroneal, and tibial nerves.
View Article and Find Full Text PDFComparison of different treatment positions of nerve slider technique for patients with low back pain: a randomized control trial.
Eur J Phys Rehabil Med
January 2025
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, European University of Lefke, Mersin, Türkiye.
Background: Low back pain (LBP) accompanied by sciatica is a widespread musculoskeletal issue with multifactorial etiology, impacting individuals across various demographics. Conservative treatments, notably physiotherapy, are key in managing LBP with sciatica, with neural mobilization techniques emerging as beneficial adjuncts.
Aim: This research aims to assess the effectiveness of utilizing the sciatic slider technique (SST) in both supine and slump positions, compared to conventional physiotherapy alone, in alleviating pain severity, improving lumbar flexibility, lumbar lordosis, lower limb muscle strength, and functional ability in patients with LBP associated with sciatica.
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