AI Article Synopsis
- The use of antibodies and nanomaterials has improved cancer treatment but issues with molecular targets lead to inconsistent effectiveness.
- A new cooperative targeting system combines synthetic and biological nanocomponents to enhance the delivery of therapeutics directly to tumor cell membranes.
- This method helps to distribute the treatment more evenly throughout the tumor, resulting in better effectiveness of phototherapy.
Article Abstract
The targeted delivery of therapeutics using antibodies or nanomaterials has improved the precision and safety of cancer therapy. However, the paucity and heterogeneity of identified molecular targets within tumours have resulted in poor and uneven distribution of targeted agents, thus compromising treatment outcomes. Here, we construct a cooperative targeting system in which synthetic and biological nanocomponents participate together in the tumour cell membrane-selective localization of synthetic receptor-lipid conjugates (SR-lipids) to amplify the subsequent targeting of therapeutics. The SR-lipids are first delivered selectively to tumour cell membranes in the perivascular region using fusogenic liposomes. By hitchhiking with extracellular vesicles secreted by the cells, the SR-lipids are transferred to neighbouring cells and further spread throughout the tumour tissues where the molecular targets are limited. We show that this tumour cell membrane-targeted delivery of SR-lipids leads to uniform distribution and enhanced phototherapeutic efficacy of the targeted photosensitizer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481829 | PMC |
| http://dx.doi.org/10.1038/ncomms15880 | DOI Listing |
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