In dental traumatology, the loss of teeth and the supporting alveolar bone in children compromise the proper development of maxillofacial structures and also limit the solutions that can be offered. In this case report, multidisciplinary management is described of a child with a significant loss of alveolar bone and associated teeth due to a traffic accident at 8 years of age. The management involved staged teeth autotransplantation into surgically prepared sites with bone expanders, orthodontic treatment and dental implants. The 3D regeneration of the alveolar process was successfully stimulated by teeth autotransplantation. At the 4-year follow-up visit, evaluation of the autotransplanted teeth and the implants indicated a successful outcome for the patient.
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http://dx.doi.org/10.1111/edt.12354 | DOI Listing |
Int J Mol Sci
December 2024
Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510000, China.
Mucosal immunity plays a critical role in the pathogenesis of inflammatory immune diseases. This study leverages single-cell RNA sequencing, spatial transcriptomics, and spatial proteomics to compare the cellular mechanisms involved in periodontitis between humans and mice, aiming to develop precise strategies to protect the gingival mucosal barrier. We identified key conserved and divergent features in cellular landscapes and transcriptional profiles across the two species, underscoring the complexity of inflammatory responses and immune dynamics in periodontitis.
View Article and Find Full Text PDFBioact Mater
April 2025
School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
After tooth extraction, alveolar bone absorbs unevenly, leading to soft tissue collapse, which hinders full regeneration. Bone loss makes it harder to do dental implants and repairs. Inspired by the biological architecture of bone, a deformable SIS/HA (Small intestinal submucosa/Hydroxyapatite) composite hydrogel coaxial scaffold was designed to maintain bone volume in the socket.
View Article and Find Full Text PDFCureus
December 2024
Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND.
Cortical laminar bone membrane (CLBM) is well known for its extraordinary mechanical properties, biocompatibility, and osteoconductive potential, and thus, it has been revealed as a revolutionary biomaterial in periodontal and alveolar bone regeneration. CLBM offers a superior alternative to traditional barrier membranes used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). CLBM represents a significant advancement in managing complex defects by overcoming common limitations such as premature degradation and inadequate soft tissue support.
View Article and Find Full Text PDFGenes Dis
March 2025
College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China.
Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy forces decelerate it. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities under different mechanical forces (MFs) remain unclear.
View Article and Find Full Text PDFJ Oral Biol Craniofac Res
December 2024
Department of dental materials, Faculty of Dentistry Medicine, Universitas Airlangga, Indonesia.
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