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Use of Escitalopram for pseudobulbar affect following severe traumatic.
J Pak Med Assoc
February 2023
Institute of Psychiatry, Rawalpindi Medical University, Rawalpindi,Pakistan.
Those who have suffered from traumatic brain injury (TBI) often develop behavioural, affective, and cognitive complications. Some might experience episodes of involuntary and/or exaggerated laughter and crying. This condition is commonly known as 'pseudobulbar affect'(PBA) and leads to anger, frustration, and social disability.
View Article and Find Full Text PDFThe manifestation of affective symptoms in multiple sclerosis and discussion of the currently available diagnostic assessment tools.
J Neurol
January 2023
Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Introduction: In addition to physical and cognitive symptoms, patients with multiple sclerosis (MS) have an increased risk of experiencing mental health problems.
Methods: This narrative review provides an overview of the appearance and epidemiology of affective symptoms in MS such as depression, anxiety, bipolar disorder, euphoria, and pseudobulbar affect. Furthermore, the association between affective symptoms and quality of life and the currently used diagnostic instruments for assessing these symptoms are considered whereby relevant studies published between 2009 and 2021 were included in the review.
A missing link in affect regulation: the cerebellum.
Soc Cogn Affect Neurosci
December 2022
Department of Psychology, Temple University, Philadelphia, PA 19122, USA.
The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes.
View Article and Find Full Text PDFPseudobulbar Affect Presenting as Aggressive Behavior.
Cureus
February 2022
Psychiatry, Brookdale University Hospital Medical Center, Brooklyn, USA.
Pseudobulbar affect (PBA) is an affective disorder of emotional expression characterized by frequent uncontrollable outbursts of laughing or crying. It is usually associated with stroke, traumatic brain injury, and other neurological conditions. This disorder can present a challenge to clinicians to distinguish this from mood disorders or to diagnose this disorder in the context of underlying mood disorders.
View Article and Find Full Text PDFTreatment of disorders of emotional comprehension, expression, and emotional semantics.
Handb Clin Neurol
August 2021
Research Service and the Brain Rehabilitation Research Center, Malcom Randall Veteran Affairs Medical Center, Gainesville, FL, United States; Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States. Electronic address:
Neurological disease can impair emotional communication by several means: damaging the networks important in understanding the meaning of emotional stimuli (emotional semantics); damaging networks important in the perceptual recognition and production of emotional stimuli, and damaging the connections between networks supporting emotional semantics and recognition/production networks. Disorders of emotional expression, comprehension, and emotional semantics may improve with pharmacological or behavioral treatments. Pharmacological treatments can be used to redress naturally occurring or disease-related alterations in the computational properties of target neural systems.
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