AI Article Synopsis

  • - Type 2 diabetes is the most common form of diabetes found in both humans and nonhuman primates, with limited understanding of its causes and preventive measures in nonhuman studies.
  • - This research examined how housing arrangements, exercise, diet, age, and sex influence diabetes-related metrics like fasting plasma glucose, lipids, and body weight in nonhuman primates.
  • - Key findings revealed that exercise and housing type significantly impact body weight and glucose levels, with age and sex also affecting metabolic profiles, highlighting factors that could help prevent diabetes in humans.

Article Abstract

Type 2 diabetes mellitus is the most common form of diabetes that occurs in both human and nonhuman primates. Although spontaneously diabetic nonhuman primates are used extensively in diabetic related research and are a proven valuable tool for the study of the natural history of diabetes, little is known about the key factors that can cause this metabolic disorder and the preventative measures that could be employed to minimize the consequences of diabetes. Using a model of developing and untreated diabetes, this study describes the effects of housing arrangement (socially group- versus individually single-housed), exercise, diet, age, and sex on fasting plasma glucose, key lipids associated with diabetes, and bodyweight in two large cohorts of nonhuman primates. Key findings include exercise/housing arrangement's contribution to significant differences in bodyweight, levels of fasting plasma glucose, total cholesterol, and high- and low-density lipoproteins. Age also had profound effects on glucose, triglyceride and high-density lipoproteins, particularly in single-caged animals. Moreover, females had higher fasting glucose, total cholesterol and triglyceride levels than male counterparts within the same housing situations. These factors may be critical to identifying preventive measures that could eventually be used to minimize obesity and diabetes in humans.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2017.06.010DOI Listing

Publication Analysis

Top Keywords

nonhuman primates
12
exercise diet
8
diet age
8
developing untreated
8
diabetes
8
untreated diabetes
8
fasting plasma
8
plasma glucose
8
glucose total
8
total cholesterol
8

Similar Publications

Granulomas, organized aggregates of immune cells which form in response to (), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the existing literature on such determinants.

View Article and Find Full Text PDF

The Sichuan golden snub-nosed monkey (Rhinopithecus roxellana) is a rare and endangered species endemic to China that occupies a particularly important position in the evolutionary history of Rhinopithecus species. Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. We review the current limited literature on the dental characteristics and dental pathologies related to the golden snub-nosed monkey, based on skeleton data and morphological evidence.

View Article and Find Full Text PDF

Intergroup competition for limited resources is a significant selection pressure that drives the evolution of animal society. The rhesus macaque (Macaca Mulatta) is the most widely distributed nonhuman primate in the world and can adapt well to environments disturbed by humans. In some areas, human provisioning provides ample food resources for rhesus macaques, leading to an increase in their population size, inevitably affecting competition patterns within and between groups.

View Article and Find Full Text PDF

Placental and Fetal Microbiota in Rhesus Macaque: A Case Study Using Metagenomic Sequencing.

Am J Primatol

January 2025

Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China.

Recent evidence challenging the notion of a sterile intrauterine environment has sparked research into the origins and effects of fetal microbiota on immunity development during gestation. Rhesus macaques (RMs) serve as valuable nonhuman primate models due to their similarities to humans in development, placental structure, and immune response. In this study, metagenomic analysis was applied to the placenta, umbilical cord, spleen, gastrointestinal tissues of an unborn RM fetus, and the maternal intestine, revealing the diversity and functionality of microbes in these tissues.

View Article and Find Full Text PDF

Variation in the efficiency of extracting calorie-rich and nutrient-dense resources directly impacts energy expenditure and potentially has important repercussions for cultural transmission where social learning strategies are used. Assessing variation in efficiency is key to understanding the evolution of complex behavioural traits in primates. Here we examine evidence for individual-level differences beyond age- and sex-class in non-human primate extractive foraging efficiency.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: