We report a divergent and modular protocol for the preparation of acyclic molecular frameworks containing newly created quaternary carbon stereocenters. Central to this approach is a sequence composed of a (1) regioselective and -retentive preparation of allyloxycarbonyl-trapped fully substituted stereodefined amide enolates and of a (2) enantioselective palladium-catalyzed decarboxylative allylic alkylation reaction using a novel bisphosphine ligand.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555155 | PMC |
http://dx.doi.org/10.1021/jacs.7b04086 | DOI Listing |
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