Objectives: To provide a quantitative estimation of motor fluctuations in PD through a 12-h Waking-day Motor Assessment (WDMA) and to develop new WDMA-based tools, the Motor Fluctuation Indices.
Methods: Two independent samples of PD patients (exploratory population N = 51, testing population N = 109) were examined. Patients underwent a WDMA using the Unified Parkinson's Disease Rating Scale (UPDRS) and were classified as either having or not having motor fluctuations. To quantify motor fluctuations, the Worsening Index (WI), the Mean Fluctuation Index (MFI) and the Coefficient of Variation (CV) were computed. The optimal cut-off for each index distinguishing patients with or without fluctuations was calculated on the exploratory population. Cut-offs' accuracy was then verified in the testing population.
Results: Optimal cut-off scores to differentiate stable patients from fluctuating ones were 8.3 for WI, 5 for MFI and 12.9 for CV. Sensitivity and a specificity were 91.2% (95%CI: 85.9 to 96.5) and 87.8% (95%CI: 81.7 to 93.9) for WI; 75% (95%CI: 66.9 to 83.1) and 90.2% (95%CI: 84.7 to 95.8) for MFI; 69.1% (95%CI: 60.4 to 77.8) and 95.1% (95%CI: 91.1 to 99.2) for CV. Patients with a larger magnitude of fluctuation had higher values for all three indices, whereas patients with multiple daily fluctuations presented only higher WI values.
Conclusions: WDMA-derived Motor Fluctuation Indices may represent reliable tools for evaluating and quantifying the severity of motor fluctuations in PD patients. Even if WDMA is a time-consuming procedure, the detection of Motor Fluctuation Indices could be helpful in assessing therapeutic efficacy on motor fluctuations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.parkreldis.2017.05.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Texas A&M University, College Station, TX, USA.
Background: Older females, particularly susceptible to Alzheimer's disease (AD), may be affected by hormonal fluctuation during life. We aim to investigate the relationship between changes in brain volume and sex steroid hormones over time. We hypothesize that levels of sex hormones (17ß-estradiol, progesterone, and testosterone) relate to changes in brain volume, especially in the hippocampus (HPC) and cerebellum (CB).
View Article and Find Full Text PDFEnergy management strategy for methanol hybrid commercial vehicles based on improved dung beetle algorithm optimization.
PLoS One
January 2025
School of Mechanical and Automotive Engineering, Anhui Polytechnic University, Wuhu, China.
In order to solve the problem of poor adaptability and robustness of the rule-based energy management strategy (EMS) in hybrid commercial vehicles, leading to suboptimal vehicle economy, this paper proposes an improved dung beetle algorithm (DBO) optimized multi-fuzzy control EMS. First, the rule-based EMS is established by dividing the efficient working areas of the methanol engine and power battery. The Tent chaotic mapping is then used to integrate strategies of cosine, Lévy flight, and Cauchy Gaussian mutation, improving the DBO.
View Article and Find Full Text PDFDeciphering brain activation during wrist movements: comparative fMRI and fNIRS analysis of active, passive, and imagery states.
Exp Brain Res
December 2024
Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Understanding the complex activation patterns of brain regions during motor tasks is crucial. Integrated functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) offers advanced insights into how brain activity fluctuates with motor activities. This study explores neuronal activation patterns in the cerebral cortex during active, passive, and imagined wrist movements using these functional imaging techniques.
View Article and Find Full Text PDFNeural correlates of basketball proficiency: An MRI study across skill levels.
J Exerc Sci Fit
January 2025
Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, People's Republic of China.
Background: Basketball is an attractive sport required both cooperative and antagonistic motor skills. However, the neural mechanism of basketball proficiency remains unclear. This study aimed to examine the brain functional and structural substrates underlying varying levels of basketball capacity.
View Article and Find Full Text PDFDuration of "Good On" time per dose: Immediate-release carbidopa-levodopa vs. extended-release carbidopa-levodopa (IPX203, CREXONT®).
Parkinsonism Relat Disord
December 2024
Amneal Pharmaceuticals, LLC, 400 Crossing Boulevard, Bridgewater, NJ, USA.
Background: For Parkinson's disease patients with motor fluctuations, the duration of benefit per levodopa dose is a key metric that reflects a patient's clinical response.
Objective: Determine the difference in mean durations of "Good On" time per dose of subjects randomized to extended-release carbidopa-levodopa (ER CD-LD; IPX203; CREXONT®) vs. immediate-release (IR) CD-LD in the RISE-PD trial.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!