AI Article Synopsis
- A new method has been created using Rh(III) as a catalyst to combine alkynyl cycloalkanols with arylamines, resulting in 1,2,3-trisubstituted indoles.
- This process utilizes a unique activation technique that involves both Csp-H and Csp-Csp bonds, showcasing innovative chemistry.
- The approach is efficient and can accommodate a wide variety of functional groups, making it versatile for different applications.
Article Abstract
A Rh(III)-catalyzed carboamination of alkynyl cycloalkanols with arylamines has been developed. This transformation involves a novel Csp-H/Csp-Csp activation relay and provides an efficient approach to versatile 1,2,3-trisubstituted indoles with a broad range of functional group tolerance.
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| http://dx.doi.org/10.1021/acs.orglett.7b01372 | DOI Listing |
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