AI Article Synopsis
- - A new, efficient method has been created to directly isolate stable α-form crystals of Mirabegron, avoiding the transformation of less stable β-form crystals.
- - This method improves upon previous techniques and eliminates the need for extra processing steps during production.
- - The process achieves an impressive yield of about 84% and a purity greater than 99.77%, determined by HPLC, all in a single step.
Article Abstract
An efficient and scalable method for the direct isolation of stable α-form crystals of Mirabegron (1) is developed. The developed method negates transformation of metastable β-form crystals into α-form crystals thereby overcoming the limitations of reported methods and avoids additional processing steps during its manufacture. The developed method directly provides stable α-form crystals of Mirabegron (1) with yield of around 84% and purity of >99.77% by HPLC in a single step.
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| http://dx.doi.org/10.17344/acsi.2017.3293 | DOI Listing |
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