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Background: Dengue, chikungunya, and Zika are mosquito-borne diseases of major human concern. Differential diagnosis is complicated in children and adolescents by their overlapping clinical features (signs, symptoms, and complete blood count results). Few studies have directly compared the three diseases.
View Article and Find Full Text PDFRecall, understanding, use, and impact of front-of-package warning labels on ultra-processed foods: A qualitative study with mothers of preschool children in Peru.
PLOS Glob Public Health
December 2024
CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
In its efforts to reduce increasing rates of obesity and nutrition-related noncommunicable diseases, Peru implemented front-of-package (FOP) warning labels (also called warnings) on processed and ultra-processed foods in June 2019. The goal was to inform consumers about high levels of sugars, saturated fats, sodium, and trans fats in packaged products. We designed a qualitative study to reveal the recall, understanding, and use of the warnings and to explore the perceived changes in purchasing behaviors among mothers of preschool children in Peru.
View Article and Find Full Text PDFDetection of SARS-CoV-2 in wastewater as an earlier predictor of COVID-19 epidemic peaks in Venezuela.
Sci Rep
November 2024
Laboratorio de Ecología de Microorganismos, Centro de Ecología Aplicada, Instituto de Zoología y Ecología Tropical, Facultad de Ciencias, Universidad Central de Venezuela (UCV), Caracas, Venezuela.
Wastewater-based epidemiological surveillance has proven to be a useful and cost-effective tool for detecting COVID-19 outbreaks. Here, our objective was to evaluate its potential as an early warning system in Venezuela by detecting SARS-CoV-2 RNA in wastewater and its correlation with reported cases of COVID-19. Viral RNA was concentrated from wastewater collected at various sites in Caracas (northern Venezuela), from September 2021 to July 2023, using the polyethylene glycol (PEG) precipitation method.
View Article and Find Full Text PDFComprehension of Miranda warnings in adults with chronic, moderate-severe traumatic brain injury.
J Commun Disord
September 2024
Department of Hearing and Speech Sciences, Vanderbilt University Medical Center.
Introduction: To compare comprehension of Miranda rights in adults with traumatic brain injury (TBI) versus adults without TBI as measured by response accuracy on the Miranda Right Comprehension Instruments.
Methods: Data were collected virtually via teleconferencing from July 2022 to February 2023. Participants included 25 adults with moderate-severe TBI (12 females, 13 males) and 25 adults without TBI (12 females, 13 males), ages 20-55 years.
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy.
Cancer Cell
June 2024
Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden 2333ZA, the Netherlands. Electronic address:
Total tumor clearance through immunotherapy is associated with a fully coordinated innate and adaptive immune response, but knowledge on the exact contribution of each immune cell subset is limited. We show that therapy-induced intratumoral CD8 T cells recruited and skewed late-stage activated M1-like macrophages, which were critical for effective tumor control in two different murine models of cancer immunotherapy. The activated CD8 T cells summon these macrophages into the tumor and their close vicinity via CCR5 signaling.
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