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Tissue nanotransfection-based endothelial PLCγ2-targeted epigenetic gene editing in vivo rescues perfusion and diabetic ischemic wound healing.
Mol Ther
January 2025
Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Surgery, Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address:
Diabetic wounds are complicated by underlying peripheral vasculopathy. Reliance on vascular endothelial growth factor (VEGF) therapy to improve perfusion makes logical sense, yet clinical study outcomes on rescuing diabetic wound vascularization have yielded disappointing results. Our previous work has identified that low endothelial phospholipase Cγ2 (PLCγ2) expression hinders the therapeutic effect of VEGF on the diabetic ischemic limb.
View Article and Find Full Text PDFAll-solid Conductive Elastomers Bridging Mechanical Performance and Sustainability for Durable and Multifunctional Electronics.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Fire Science, University of Science and Technology of China, 443 Huangshan Road, Hefei 230027, P. R.China.
The next generation of stretchable electronics seeks to integrate superior mechanical properties with sustainability and sensing stability. Ionically conductive and liquid-free elastomers have gained recognition as promising candidates, addressing the challenges of evaporation and leakage in gel-based conductors. In this study, a sustainable polymeric deep eutectic system is synergistically integrated with amino-terminated hyperbranched polyamide-modified fibers and aluminum ions, forming a conductive supramolecular network with significant improvements in mechanical performance.
View Article and Find Full Text PDFIntegrating Remote Sensing and Soil Features for Enhanced Machine Learning-Based Corn Yield Prediction in the Southern US.
Sensors (Basel)
January 2025
United States Department of Agriculture-Agriculture Research Service, Grassland Soil and Water Research Laboratory, Temple, TX 76502, USA.
Efficient and reliable corn ( L.) yield prediction is important for varietal selection by plant breeders and management decision-making by growers. Unlike prior studies that focus mainly on county-level or controlled laboratory-scale areas, this study targets a production-scale area, better representing real-world agricultural conditions and offering more practical relevance for farmers.
View Article and Find Full Text PDFNovel Insights into Surface Energies and Enhanced Gas-Sensing Capabilities of ZnGaO(111) via Ab Initio Studies.
Sensors (Basel)
January 2025
Graduate Institute of Precision Engineering, National Chung Hsing University, No. 145, Xingda Road, Taichung 40227, Taiwan.
This study investigates the surface energies and work function changes in ZnGaO(111) surfaces with different atomic terminations using ab initio density functional theory. It explores the interactions of gas molecules such as NO, NO, and CHCOCH with Ga-terminated, O-terminated, and Ga-Zn-O-terminated surfaces. This study reveals previously unreported insights into how O-terminated surfaces exhibit enhanced reactivity with NO, resulting in significant work function changes of +6.
View Article and Find Full Text PDFAll-Metal Metamaterial-Based Sensor with Novel Geometry and Enhanced Sensing Capability at Terahertz Frequency.
Sensors (Basel)
January 2025
Department of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza" University of Rome, 00184 Rome, Italy.
This research proposes an all-metal metamaterial-based absorber with a novel geometry capable of refractive index sensing in the terahertz (THz) range. The structure consists of four concentric diamond-shaped gold resonators on the top of a gold metal plate; the resonators increase in height by 2 µm moving from the outer to the inner resonators, making the design distinctive. This novel configuration has played a very significant role in achieving multiple ultra-narrow resonant absorption peaks that produce very high sensitivity when employed as a refractive index sensor.
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