Background: Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it's in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. A series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with P. multocida type B, serotype 2.
Results: The ratio of the 24 h area under the concentration-time curve divided by the minimum inhibitory concentration (AUCTCF/MIC) was the best PK/PD index correlated with the in vivo antibacterial effectiveness of marbofloxacin (R2 = 0.9279). The AUCTCF/MIC necessary to achieve a 1-log CFU/ml reduction and a 3-log CFU/ml (90% of the maximum response) reduction as calculated by an inhibitory sigmoid E model were 13.48 h and 57.70 h, respectively.
Conclusions: Marbofloxacin is adequate for the treatment of swine infected with P. multocida. The tissue-cage model played a significant role in achieving these PK/PD results.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471993 | PMC |
http://dx.doi.org/10.1186/s12917-017-1099-z | DOI Listing |
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