AI Article Synopsis
- Gastrointestinal cancer is a leading cause of death globally, with hereditary syndromes accounting for 5-10% of all cases.
- Advances in genomics have identified several cancer predisposition genes linked to these cancers, suggesting that many undiagnosed cases may have a hereditary basis.
- Physicians need to recognize these hereditary syndromes to identify at-risk patients and consider genetic testing, which is crucial for prevention and management of gastrointestinal cancers.
Article Abstract
Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes.
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| http://dx.doi.org/10.15403/jgld.2014.1121.262.maj | DOI Listing |
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