[Clinical and molecular genetic analysis of a case of familial multiple sclerosis in the Republic of Bashkortostan].

Aim: To investigate clinical manifestations of multiple sclerosis (MS) and the genetic makeup of six affected members of one family.

Material And Methods: Six members of the family of Russian ethnic origin were examined. Pedigree analysis and genotyping of polymorphic markers of candidate genes for multiple sclerosis were performed.

Results And Conclusion: The accumulation of alleles that were associated with autoimmune diseases according to the results of genome-wide association studies (rs1109670*C, rs3129934*T, rs9523762*G, rs1570538*T) was found in the family. The results confirm the contribution of several genetic variants to familial forms of MS.