Two new steroids, crellasterones A () and B (), together with the previously reported compound chalinasterol () and several nucleosides (-), were isolated from the sponge , collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484127 | PMC |
| http://dx.doi.org/10.3390/md15060177 | DOI Listing |
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Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans.
Mar Drugs
June 2017
Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney NSW 2109, Australia.
Two new steroids, crellasterones A () and B (), together with the previously reported compound chalinasterol () and several nucleosides (-), were isolated from the sponge , collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.
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