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Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy.
Mol Ther Nucleic Acids
March 2025
Program of Infection and Inflammation, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Currently, no approved antiviral drugs target dengue virus (DENV) infection, leaving treatment reliant on supportive care. DENV vaccine efficacy varies depending on the vaccine type, the circulating serotype, and vaccine coverage. We investigated defective interfering particles (DIPs) and lipid nanoparticles (LNPs) to deliver DI290, an anti-DENV DI RNA.
View Article and Find Full Text PDFThe ethanol extract of as an ovicidal agent against .
Narra J
December 2024
Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Dengue hemorrhagic fever (DHF) is a major health concern in tropical and subtropical countries. Indonesia has DHF cases perennially every year. On the other hand, Indonesia is abundant with seaweed ), which can be found across its seashore.
View Article and Find Full Text PDFLeukopenia and thrombocytopenia in dengue patients presenting in the emergency department of a tertiary center in Nepal: a cross-sectional study.
BMC Infect Dis
January 2025
Department of Dermatology, Civil Service Hospital, Kathmandu, Nepal.
Introduction: Dengue viruses cause either symptomatic infections or asymptomatic seroconversion. Symptomatic dengue has a wide clinical spectrum ranging from self-limiting infection to severe manifestations, mostly characterized by plasma leakage with or without hemorrhage. World Health Organization classification in 2009 classified dengue into dengue without warning signs, dengue with warning signs, and severe dengue.
View Article and Find Full Text PDFLeveraging dynamics informed neural networks for predictive modeling of COVID-19 spread: a hybrid SEIRV-DNNs approach.
Sci Rep
January 2025
Institute of Mathematical Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
A dynamics informed neural networks (DINNs) incorporating the susceptible-exposed-infectious-recovered-vaccinated (SEIRV) model was developed to enhance the understanding of the temporal evolution dynamics of infectious diseases. This work integrates differential equations with deep neural networks to predict time-varying parameters in the SEIRV model. Experimental results based on reported data from China between January 1, and December 1, 2022, demonstrate that the proposed dynamics informed neural networks (DINNs) method can accurately learn the dynamics and predict future states.
View Article and Find Full Text PDFInsecticidal effects of Sargassum vulgare and Caulerpa racemosa extracts on Aedes aegypti.
Parasitol Int
January 2025
Department of Fundamental Chemistry, Center for Natural Sciences, Federal University of Pernambuco, Av. Jorn. Aníbal Fernandes, s/n - Cidade Universitária, 50740-560 Recife, Pernambuco, Brazil. Electronic address:
Dengue is a viral disease present in many regions of the world. Aedes aegypti transmits it, and the most effective way to eliminate the mosquito is during the larval stage. Seaweeds possess metabolites with insecticidal properties, making them potential sources of new larvicides and viable alternatives to synthetic products used to control insect vectors of diseases.
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