Forkhead box transcription factor L2 activates to regulate insect chorion formation.

Most animals are oviparous. However, the genes regulating egg shell formation remain not very clear. In this study, we found that Forkhead box transcription factor L2 (FoxL2) directly activated follicle cell protein 3C () to regulate chorion formation. and had a similar expression pattern, both highly expressed in the follicular cells of female adults. Knockdown of or also resulted in the same phenotypes: obesity and female infertility. RNA interference (RNAi) results suggested that is a downstream gene of Furthermore, transient expression showed that FoxL2 could directly activate the promoter. These results suggest that is a direct target gene of FoxL2. Depletion of or prevented normal chorion formation. Our results first revealed the functions of Fcp3C and FoxL2 in regulation of oocyte maturation in an oviparous animal.