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Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.
Mol Neurodegener
September 2024
Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
Background: Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that microglial activation is regionally synchronized in the healthy brain but experiences regional desynchronization with ongoing neurodegenerative disease. We addressed the existence of a microglia connectome and investigated microglial desynchronization as an AD biomarker.
View Article and Find Full Text PDFRapid predictive dosimetry for Second Strike prescription based on whole body radioiodine kinetics in differentiated thyroid cancer.
Asia Ocean J Nucl Med Biol
January 2024
Department of Nuclear Medicine, The Royal Melbourne Hospital, Victoria, Australia.
Article Synopsis
- The study focuses on improving post-therapy dosimetry in systemic radionuclide therapy for thyroid cancer by using a rapid predictive dosimetry method instead of traditional multi-time point analysis.
- This method utilizes a patient's specific time-activity curve for accurate dose calculations based on their exposure rates, which streamlines the prescription process for follow-up treatment.
- A Predictive Calculator spreadsheet has been developed to make this predictive dosimetry accessible and efficient for use in clinical settings.
Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [F]Florzolotau PET imaging and subtype/stage inference algorithm.
EBioMedicine
November 2023
Department of Nuclear Medicine, Inselspital, University of Bern, Bern, Switzerland; Department of Informatics, Technical University of Munich, Munich, Germany.
Background: Progressive supranuclear palsy (PSP) is a primary 4-repeat tauopathy with diverse clinical phenotypes. Previous post-mortem studies examined tau deposition sequences in PSP, but in vivo scrutiny is lacking.
Methods: We conducted [F]Florzolotau tau positron emission tomography (PET) scans on 148 patients who were clinically diagnosed with PSP and 20 healthy controls.
QuADRANT: a study on uptake and implementation of clinical audit of medical radiological procedures in Europe-expert recommendations for improvement, endorsed by the ESR.
Insights Imaging
May 2023
Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health Sciences, St. James' Hospital, Dublin, Ireland.
Background: QuADRANT was a study funded by the European Commission to evaluate clinical audit uptake and implementation across Europe, with an emphasis on clinical audit as mandated within the BSSD (Basic Safety Standards Directive).
Aims: QuADRANT objectives-obtain an overview of European clinical audit activity; identify good practices and resources, barriers and challenges; provide guidance and recommendations going forwards; identify the potential for European Union action on quality and safety in the three core project specialties, radiology, radiotherapy and nuclear medicine.
Findings And Recommendations: QuADRANT identified that developments in national clinical audit infrastructure are required.
Clinical audit is an important quality improvement activity and has significant benefits for patients in terms of enhanced care, safety, experience and outcomes. Clinical audit in support of radiation protection is mandated within the European Council Basic Safety Standards Directive (BSSD), 2013/59/Euratom. The European Society of Radiology (ESR) has recognised clinical audit as an area of particular importance in the delivery of safe and effective health care.
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