AI Article Synopsis
- - Retinoids, which are derivatives of vitamin A, show potential antitumor effects against hepatocellular carcinoma (HCC), but their action can be inhibited by the protein PRAME, which interferes with retinoic acid signaling.
- - A study analyzed PRAME mRNA expression in cancer and non-cancer tissues from 100 HCC patients, revealing key connections between PRAME levels, cancer stage, tumor markers, and patient survival outcomes.
- - The research suggests that PRAME could serve as a new prognostic marker for HCC, even though its mechanism of action doesn't directly involve the RA transcriptional pathway.
Article Abstract
Background: Retinoids, vitamin A and its derivatives, have an antitumor effect on hepatocellular carcinoma (HCC). The function of retinoids is exerted by the complex of retinoic acid (RA) with the heterodimer of retinoid X receptor and the RA receptor. The preferentially expressed antigen of melanoma (PRAME) acts as a dominant repressor of RA signaling by binding to the complex. The significance of PRAME on the prognosis of HCC remains to be clarified.
Methods: PRAME mRNA expression was examined by quantitative real-time polymerase chain reaction in both tumor and non-tumor tissues of 100 HCC patients who received surgical resection. The effect of PRAME knockdown on DR5-mediated RA transcriptional activity was examined.
Results: In tumor tissues, there were significant associations among PRAME expression, clinical stage, tumor markers, and tumor numbers. In non-tumor tissues, there were significant associations among PRAME expression, overall survival, and disease-free survival. The knockdown of PRAME caused no reduction in DR5-mediated transcriptional activity of RA, suggesting that PRAME acts via other mechanisms than the DR5 RA-responsive elements.
Conclusion: Our findings indicate that PRAME expression is a novel prognostic marker in HCC patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465675 | PMC |
| http://dx.doi.org/10.1159/000448137 | DOI Listing |
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