The Shift of the Intestinal Microbiome in the Innate Immunity-Deficient Mutant Strain of upon Orsay Virus Infection.

The status of intestinal microbiota is a determinant of host health. However, the alteration of the gut microbiota caused by the innate immune response to virus infection is unclear. and its natural virus Orsay provide an excellent model of host-virus interactions. We evaluated the intestinal microbial community complexity of the wild-type N2 and the innate immunity-deficient mutant () strains of upon Orsay virus infection. The gut microbiota diversity was decreased in () mutant animals, and a large number of genes were associated with the difference between infected and uninfected () mutant animals. Therefore, this study provides the first evaluation of the alterations caused by Orsay virus on intestinal microbiota in wildtype and innate immunity-deficient animals using as the model species. Our findings indicate that virus infection may alters the microbiome in animals with defective immune response.