In many dermatological applications, lowering the temperature of skin and maintaining specific temperatures for extended periods of time are fundamental requirements for treatment; for example, in targeting adipose tissue and managing cutaneous pain. In this work, we investigate the feasibility of using phase changing materials (PCMs) as an alternative passive, open-loop, heat extraction method for cooling cutaneous and subcutaneous tissues. We used a finite difference parametric approach to model the spatial and temporal progression of the heat transferred from the skin to a PCM in contact with the skin surface. We modelled the thermal performance of different PCMs, including different thicknesses. In addition, we used our model to propose application strategies. Numerical simulations demonstrate the feasibility of using PCMs for extracting heat from the skin and upper fat layers, inducing and maintaining similar temperatures as those induced by active closed-loop cooling with a cold plate. In terms of development, the critical design parameters are the temperature range of solidification of the material, the thickness of the material, and the rate of melting. Our study suggests that PCM-based devices may offer an alternative skin and adipose tissue cooling method that is simple to implement and use.

Download full-text PDF

Source
http://dx.doi.org/10.1080/02656736.2017.1342872DOI Listing

Publication Analysis

Top Keywords

cooling cutaneous
8
cutaneous subcutaneous
8
subcutaneous tissues
8
phase changing
8
changing materials
8
adipose tissue
8
skin
5
passive cooling
4
tissues phase
4
materials feasibility
4

Similar Publications

Intranasal Treatment with Cannabinoid 2 Receptor Agonist HU-308 Ameliorates Cold Sensitivity in Mice with Traumatic Trigeminal Neuropathic Pain.

Cells

November 2024

Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Post-traumatic trigeminal neuropathy (PTTN) is a sensory abnormality caused by injury to the trigeminal nerve during orofacial surgery. However, existing analgesics are ineffective against PTTN. Abnormal microglial activation in the caudal part of the spinal trigeminal nucleus caudal part (Sp5C), where the central trigeminal nerve terminals reside, plays an important role in PTTN pathogenesis.

View Article and Find Full Text PDF

Gellan gum-based multifunctional hydrogel with enduring sterilization and ROS scavenging for infected wound healing.

Int J Biol Macromol

December 2024

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:

The progression of severe skin injury healing can be easily impeded by bacterial infections and the resultant overproduction of reactive oxygen species (ROS) within the wound microenvironment. In this study, we developed a multifunctional antibacterial hydrogel by integrating gallium ion-tannic acid and polydopamine particles into gellan gum via a facile heat-cooling process. By harnessing the synergistic effects of polydopamine for short-term photothermal therapy and gallium ion for long-term chemotherapy, the hydrogel obtained shows outstanding antibacterial activities.

View Article and Find Full Text PDF
Article Synopsis
  • Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
  • Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
  • Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
View Article and Find Full Text PDF

Chemotherapy-Induced Alopecia by Docetaxel: Prevalence, Treatment and Prevention.

Curr Oncol

September 2024

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Docetaxel is a commonly used taxane chemotherapeutic agent in the treatment of a variety of cancers, including breast cancer, ovarian cancer, prostate cancer, non-small cell lung cancer, gastric cancer, and head and neck cancer. Docetaxel exerts its anti-cancer effects through inhibition of the cell cycle and induction of proapoptotic activity. However, docetaxel also impacts rapidly proliferating normal cells in the scalp hair follicles (HFs), rendering the HFs vulnerable to docetaxel-induced cell death and leading to chemotherapy-induced alopecia (CIA).

View Article and Find Full Text PDF

Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor.

J Dermatol Sci

September 2024

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea; (b)Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!