Objective: The aim of this study was to revisit and further investigate the association between menopause and disc degeneration in the lumbar spine using a magnetic resonance imaging-based eight-level grading system.
Methods: This study cohort comprised of 1,566 women and 1,382 age-matched men who were admitted for low back pain from June 2013 to October 2016. Data on age, weight, height, body mass index, age at natural menopause, and years since menopause (YSM) were obtained. Lumbar disc degeneration was assessed using a magnetic resonance imaging-based eight-level grading system.
Results: After adjustment for the confounding factors of age, height, and weight, young age-matched men were more susceptible to disc degeneration than premenopausal women (P < 0.05). However, after menopause, postmenopausal women had a significant tendency to develop more severe disc degeneration than their age-matched men (P < 0.05), and also compared with premenopausal and perimenopausal women (P < 0.01). Postmenopausal women were divided into nine subgroups by every 5 YSM. When YSM was less than 15 years, a positive trend was observed between YSM and severity of disc degeneration, respectively, at L1/L2 (r = 0.241), L2/L3 (r = 0.193), L3/L4 (r = 0.191), L4/L5 (r = 0.165), L5/S1 (r = 0.153), and all lumbar discs (r = 0.237) (P < 0.05 or 0.01). The analysis of covariance indicated a significant difference in each disc level (P < 0.05 or 0.01) between every two groups. When YSM was more than 15 years, the significant difference, however, disappeared in each disc level (P > 0.05).
Conclusions: Menopause is associated with lumbar disc degeneration. The association occurred in the first 15 YSM, suggesting estrogen deficiency might be a risk factor of disc degeneration of the lumbar spine. Further studies need to be carried out for deciding whether age or menopause plays a more important role in the progression of disc degeneration in the lumbar spine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/GME.0000000000000902 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies.
Acta Biomater
January 2025
Department of Industrial Engineering, School of Engineering and Architecture, University of Bologna, Viale del Risorgimento 2, 40136, Bologna, Italy. Electronic address:
Intervertebral disc (IVD) degeneration is suspected to affect the distribution of stress and strain near the vertebral endplates and in the underlying bone. This scenario is worsened by the presence of metastatic lesions on the vertebrae (primarily thoracic vertebrae (60-80%)) which increase the risk of fracture. As such, this study aimed to evaluate the effect of IVD degeneration on the internal volumetric strains and failure modes of human metastatic vertebral bodies.
View Article and Find Full Text PDFClinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs.
J Vet Intern Med
January 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Background: Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described.
Hypothesis/objectives: To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy.
Animals: Three hundred seventy-seven client-owned dogs from 2010 to 2022.
Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion.
J Orthop Surg Res
January 2025
Hebei Orthopaedic Research Institute, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P.R. China.
Objective: The postoperative recovery of patients with lumbar disc herniation (LDH) requires further study. This study aimed to establish and validate a predictive model for functional recovery in patients with LDH and explore associated risk factors.
Method: Patients with LDH undergoing PLIF admitted from January 1, 2018 to December 31, 2022 were included, and patient data were prospectively collected through follow-up.
Patient-specific spine digital twins: a computational characterization of the idiopathic scoliosis.
J Orthop Surg Res
January 2025
Biomedical Engineering Department, Universidad de los Andes, Bogotá, Colombia.
Article Synopsis
- Scoliosis is identified through Cobb's angle, and this study aims to create a digital twin of the spine to analyze biomechanical stresses and disc degeneration related to idiopathic scoliosis using patient-specific data.
- A 3D computational model was developed that modifies intervertebral disc properties based on radiological measurements, validated by comparing with patient images; finite element analysis clarified the impact of deformity on spinal biomechanics.
- The results showed that the model accurately represented thoracic scoliosis and revealed that disc strain increases near the apex, with "type-C" curves at higher risk for herniation compared to "type-S," thereby enhancing understanding of scoliosis and aiding in treatment planning.
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.
J Orthop Surg Res
January 2025
Department of Orthopaedics, Qilu Hospital of Shandong University, No.107, Wenhuaxi Road, Lixia District, Jinan, Shandong Province, 250012, China.
Background: Ferroptosis was involved in the pathogenesis of intervertebral disc degeneration (IVDD). However, the exact mechanism of IVDD associated with ferroptosis still required deeper studies.
Method: The differentially expressed genes (DEGs) in rat lumbar disc tissue between the control and IVDD group treated with IL-1β were detected by RNA sequencing (RNA-seq).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!