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| http://dx.doi.org/10.7812/TPP/16-149 | DOI Listing |
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Alzheimers Dement
December 2024
Amsterdam UMC, Amsterdam, Amsterdam, Netherlands.
Background: Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioral variant of frontotemporal dementia (bvFTD) are hypothesized to be the extreme ends of the ALS-bvFTD spectrum. This spectrum also encompasses ALS patients with mild to severe cognitive impairment (ALSci) and/or behavioral impairment (ALSbi), including ALS with concomitant bvFTD. In a previous study, using magnetoencephalography (MEG), in early symptomatic ALS patients we showed resting-state functional connectivity changes in frontal, limbic and subcortical regions that overlap considerably with bvFTD.
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Alzheimers Dement
December 2024
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, UNSW Sydney, NSW, Australia.
Background: Harmonization of neuropsychological assessment for vascular cognitive disorders (VCD) is important for ensuring the highest standards for diagnostic and post-diagnostic care. A battery jointly proposed by the NINDS-CSN has received much support. Considering significant developments in the field, and an urgent need for consensus on remote and computerised assessment methods, an international expert group was commissioned to develop an updated harmonized battery and associated assessment guidelines for VCD using the Delphi process.
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Alzheimers Dement
December 2024
University of Melbourne, Parkville, VIC, Australia.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative condition, with considerable variation in disease progression from the mild cognitive impairment (MCI) stage. Predicting disease progression will support prognostic decisions and patient management. Here we designed a machine learning (ML) stack model, where a classifier was used to differentiate MCI progressors from non-progressors (i.
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Alzheimers Dement
December 2024
Washington University in St. Louis, St. Louis, MO, USA.
The widespread use of remote digital assessment technology has made it possible to obtain high-frequency measurements of cognitive function in naturalistic settings (i.e., outside of the clinic).
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Alzheimers Dement
December 2024
UT Health San Antonio, San Antonio, TX, USA.
Background: Motivational disturbances are a major harbinger for dementia, being associated with a two- to seven-fold higher conversion rate from mild cognitive impairment. However, there are currently no objective assessment methods for identifying motivational disturbances in older adults (OA). Here, we present preliminary findings from a larger study which aims to validate an objective behavioral measure of effort in OAs by investigating the effects of age, risk, and reward (gain vs.
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