AI Article Synopsis
- Galactomannan (ACP) was extracted from the Taiwanese medicinal mushroom Antrodia cinnamomea, and its chemical structure was analyzed.
- ACP was found to significantly boost the ability of J774A.1 murine macrophages to engulf and kill Escherichia coli.
- This suggests ACP could be a potential candidate for new immunomodulatory treatments or as an adjuvant in vaccines and immunotherapy.
Article Abstract
Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Taiwan medicinal mushroom Antrodia cinnamomea, and its chemical structure was determined herein. ACP significantly enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
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| http://dx.doi.org/10.1021/acs.orglett.7b01468 | DOI Listing |
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