AI Article Synopsis
- Dysregulation of long non-coding RNAs (lncRNAs) in the genome has been linked to cancer development and progression, highlighting their importance in the transcriptome.
- Research has identified various roles of lncRNAs in human cancers and developed strategies to target these transcripts in cancer cells.
- The review connects lncRNA expression to the DNA damage response and oxidative stress, which play critical roles in cellular damage and overall cancer biology.
Article Abstract
In addition to aberrant alternation of transcriptome, it is now suggested that dysregulation of the non-coding transcripts, particularly long non-coding RNAs (lncRNAs), which comprise the majority of the genome, is contributed to cancer initiation and progression. As the result of recent huge efforts, the possible roles of numerous lncRNAs in the human cancers were characterized, as well as various strategies with inhibitory effects to target these transcripts on the transformed cells. Moreover, DNA damage response (DDR) pathway is a complex regulatory network responsible for the identification of disruptions in DNA structure, integrity and stability- it is reported to be associated with the up-regulation and down-regulation of lncRNAs. This review explores the involvement of the various lncRNAs in different human cancers, afterwards discusses the association of the lncRNAs expression with the DDR and oxidative stress, which are implicated in a myriad pathophysiological and physiological intra- and extracellular damages. J. Cell. Biochem. 119: 223-236, 2018. © 2017 Wiley Periodicals, Inc.
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