Highly type-specific soluble antigens (SA) of viruses of the tick-borne encephalitis (TBE) complex were obtained by treatment of the sucrose-acetone antigens with 8 mol/l urea. Each SA reacted with the homologous serum only. The serum to SA of strain Sofyin and of Omsk haemorrhagic fever virus distinguished the TBE complex representatives; the difference between homologous serum titres was in the range of 4-5 two-fold dilution steps.
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