The highly enantioselective cyclization of 3-alkenylindole via C-H activation has been established using Pd(OCOCF) in conjunction with the chiral spiro bis(isoxazoline) ligand (SPRIX). The presence of an N-allyl substituent on the substrate has a strong impact on both reactivity and selectivity, leading to tricyclic indole products (up to 96% ee) with a chiral quaternary carbon center.
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