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It's only a matter of time: longevity of cocaine-induced changes in dendritic spine density in the nucleus accumbens. | LitMetric

It's only a matter of time: longevity of cocaine-induced changes in dendritic spine density in the nucleus accumbens.

Curr Opin Behav Sci

Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, USA 75390-9070.

Published: February 2017

AI Article Synopsis

Article Abstract

Many reports show that repeated cocaine administration increases dendritic spine density in medium spiny neurons of the nucleus accumbens, but there is less agreement regarding the persistence of these changes. In this review we examine these discrepancies by systematically categorizing papers that measured cocaine-induced changes in accumbal spine density. We compare published reports based on withdrawal time, short versus long duration of cocaine administration, environmental pairing with cocaine, and core/shell subregion specificity. Together, these studies suggest that cocaine exposure induces rapid and dose-dependent increases in spine density in accumbens neurons that may play a role in the maintenance of cocaine use and vulnerability to early relapse, but are not a factor in behavioral changes associated with longer abstinence.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465866PMC
http://dx.doi.org/10.1016/j.cobeha.2016.11.013DOI Listing

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